Use the Reduces vertices function to simplify a polyline removing not significant vertexes, for example along an alignment.
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Click Edit.
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Click Reduce vertices.
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Select the polyline.
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Select the vertices reduction mode:
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2D distance: vertices are removed if the 2D distance from point to alignment is smaller than entered value.
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3D distance: vertices are removed if the 3D distance from point to alignment is smaller than entered value.
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Confirm the selection.